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Economic analysis on Haemophilus influenzae b, chickenpox, pneumococcal, hepatitis A and combination vaccines in the Childhood Immunisation Programme in Hong Kong |
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| Funds
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Research Fund for the Control of Infectious Diseases (commissioned projects) |
| Project
Status |
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Closed |
| Reference
No. |
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CHP-CE-02 |
| Project
Title |
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Economic analysis on Haemophilus influenzae b, chickenpox, pneumococcal, hepatitis A and combination vaccines in the Childhood Immunisation Programme in Hong Kong |
| Applicant(s) |
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McGhee SM
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| Affiliation(s) |
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Centre for Health Protection
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| Approved
Amount (HK$) |
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$926,000.00 |
| Abstract |
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Aim:
To examine the economic implications of changing childhood immunisation programme in Hong Kong, with emphasis inclusion of Haemophilus influenzae B, varicella, pneumococcal, hepatitis A and/or combination vaccine(s) in the childhood immunisation programme.
Methods:
A decision-analytic model simulating a cohort of children over a set number of years will be constructed to compute outcomes and costs. Data on disease prevalence, vaccine effectiveness and adverse effects, health care utilisation and other costs of disease, values of costs avoided and prices of vaccines will be used for modelling. Local data on disease prevalence and vaccine effect will be used where possible and overseas data suitable for the local setting as necessary. Costs will be estimated from local data. As local cost data is lacking in some areas, a telephone survey of around 400 households with young children will be conducted to determine patterns of seeking care upon child illness, costs and the implications for lost working time. The simplest model will be developed first followed by complex scenarios involving transmission dynamics and changes in the age at infection due to vaccination, with the aid of software specifically designed to model dynamic infectious disease situations. Sensitivity analyses using single and multiple parameters (Monte Carlo method) will also be performed.
Conclusion:
The final product will be a document summarising the cost-effectiveness of the various options at present, which would be a useful input to decision-making about the childhood immunisation programme in Hong Kong.
Key messages:
1. Cost-effectiveness models using local data on incidence and costs were constructed for 4 childhood vaccines: pneumococcal, varicella, Haemophilus influenzae b (Hib) and hepatitis A (hep A).
2. Pneumococcal vaccine appears highly cost-effective at a cost of $50,000 per life year saved in the main model tested and has a benefit:cost ratio of 1.7:1.
3. Hib vaccine, at a cost of $160,000 per life year saved, still falls within accepted thresholds of cost-effectiveness when given as a monovalent vaccine although, with a very conservative estimate of value of a life year, the benefit:cost ratio is only 0.8:1.
4. The varicella and hep A models had more uncertainties and further modelling might be indicated for these vaccines perhaps in conjunction with adult vaccines.
5. The models show the burdens of these 4 diseases and can be further developed and adapted as new assumptions and data become available in future. |
| Keywords |
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Haemophilus influenzae, Hib, varicella, pneumococcal, hepatitis A, hep A, vaccine, Childhood Immunisation Programme |
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