List of Approved Projects

Funded Projects List of Approved Projects

10. A Prospective Randomised Controlled Trial: Prevention of Lymphedema by Omentoplasty after Pelvic Lymphadenectomy   Funds : Health Services Research Fund Project Status : Closed Reference No. : 01030361 Project Title : A Prospective Randomised Controlled Trial: Prevention of Lymphedema by Omentoplasty after Pelvic Lymphadenectomy Applicant(s) : Ng TY Chan YM Tam KF Ngan YSH Affiliation(s) : Department of Obstetrics, The University of Hong Kong Approved Amount (HK$) : $187,959.00 Abstract : Purpose:To see whether omentoplasty can reduce the occurrence of lymphedema after staging surgery with lymphadenectomy in carcinoma of the cervix and carcinoma of the corpus.Objectives/hypothesis:Lymphedema is a debilitating condition that occurs in up to 40% of patients after pelvic lymphadenectomy. New surgical techniques have been advocated to reduce this complication. A pilot study using omentoplasty observed that 8% of patients after this procedure had clinical lymphedema compared with 40% in historical controls. This study aims to see whether these preliminary results are validated in a prospective randomised comparison.Design and subjects:All patients undergoing radical hysterectomy for carcinoma of the cervix or extended surgical staging for carcinoma of the corpus which involves pelvic node dissection (lymphadenectomy) are eligible. They will be randomised into two groups. One group will have lymphadenectomy without omentoplasty. The other group will have lymphadenectomy and omentoplasty.Interventions:Patients randomised to have omentoplasty will have this additional procedure at the end of staging surgery. This involves taking a pedicled graft of the omentum and allowing it to fill up the pelvis along the iliac vessels where pelvic lymphadenectomy had been performed and the peritoneum left open. Pilot and animal studies have shown this to facilitate satisfactory lymph drainage in the abdominal cavity and along the omental flap.Main outcome measures and analysisThe primary endpoints are clinical and objective lymphedema as measured by volumetric increase at 12 months after surgery. Analysis will be by treatment actually received. Comparison of lymphedema rates will be using Pearson's Chi-square test. Keywords : lymphedema, lymphadenectomy, omentoplasty, cervix, corpus Instruments : Remarks : Dissemination Report : [PDF file] 01030361dr.pdf Final Report : [PDF file] 01030361fr.pdf [add to bookmark]

[Previous Page] [Back to Top]

[Search for Approved Projects] [List of Approved Projects] [List of RFCID - Commissioned Projects]

[Home] [Welcome] [What's New] [Call for Application] [Funds] [Research Grant Review] [Funded Projects] [Events] [Publications] [Useful Links] [Contact Us]

[Government Information Centre] [Brand Hong Kong]

2004 copyright | Important Legal Information and Disclaimer

Last revision date: 15 August 2006